Our lab investigates the molecular mechanisms of gene regulation in complex genomes, and in particular, the coordinate regulation of large multi-gene families. Our specific focus concerns the development of the olfactory system, which depends on the co-regulation of a complex ~1000-member olfactory receptor (OR) gene family. Using a variety of techniques in molecular genetics, cell biology, and comparative genomics, we investigate how this very large gene family is properly orchestrated during development of the sense of smell.
With sincere gratitude to my mentors:
- Ron Hoham at Colgate University, Hamilton, NY
- Bill Dreyer at the California Institute of Technology, Pasadena, CA
- Lee Hood at the Institute for Systems Biology, Seattle, WA
- Barb Trask at the Fred Hutchinson Cancer Research Center, Seattle, WA